Hero image Hero image It is not known if IMFINZI and IMJUDO are safe and effective in children.

How do IMFINZI + IMJUDO with chemotherapy work together?

IMFINZI + IMJUDO work with your immune system

IMFINZI and IMJUDO are immunotherapies used in combination with platinum-based chemotherapy to treat Stage 4 non-small cell lung cancer. IMFINZI and IMJUDO work with your body’s immune system to help fight cancer. Chemotherapy can help support the work of IMFINZI + IMJUDO.

IMFINZI + IMJUDO with chemotherapy may also affect healthy cells.

MEET THE KEY PLAYERS:
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Healthy Cell
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Cancer Cell
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Immune System
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IMFINZI
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IMJUDO
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Chemotherapy

How immunotherapies IMFINZI + IMJUDO work to help fight Stage 4 NSCLC:

IMFINZI + IMJUDO are immunotherapies that work with your body's immune system to help treat cancer. They may also affect healthy cells.

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The immune system serves as your body's natural defense against infections and diseases. It knows how to find and attack cancer cells when they appear in your body.

 
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Cancer cells use the proteins CTLA-4 and PD-L1 to help them escape your immune system. CTLA-4 keeps your immune cells from attacking, while PD-L1 disguises the cancer cells from your immune system.

 
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IMFINZI helps reveal the cancer cells hidden by PD-L1, and IMJUDO helps your immune cells go back on the attack.

 
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So your immune system can do what it's meant to—fight cancer cells. IMFINZI and IMJUDO may also affect healthy cells.

 

How chemotherapy works to help fight Stage 4 NSCLC:

Your immune system isn't the only defense you have. Chemotherapy can help support the work of IMFINZI + IMJUDO.

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With the help of IMFINZI + IMJUDO, your immune system works to fight cancer cells. But these cells multiply quickly.

 
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This is where chemotherapy, a type of cancer treatment, can help.

 
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Chemotherapy has the ability to destroy rapidly growing cells—such as cancer cells—throughout the body. Since chemotherapy can destroy fast-growing cells, healthy cells may also be affected.

 

What were the clinical trial results for IMFINZI + IMJUDO with chemotherapy?

See clinical trial results

Important Safety Information

What is the most important information I should know about IMFINZI® (durvalumab) and IMJUDO® (tremelimumab-actl)?

IMFINZI and IMJUDO are medicines that may treat certain cancers by working with your immune system. IMFINZI and IMJUDO can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.

What are IMFINZI and IMJUDO?

IMFINZI and IMJUDO are prescription medicines used to treat adults with a type of lung cancer called NSCLC. IMFINZI may be used in combination with IMJUDO and chemotherapy that contains platinum when your NSCLC has spread to other parts of your body (metastatic) and your tumor does not have an abnormal “EGFR” or “ALK” gene.

It is not known if IMFINZI and IMJUDO are safe and effective in children.

Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:

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Lung problems: cough, shortness of breath, and chest pain

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Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; and severe stomach-area (abdomen) pain or tenderness

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Liver problems: yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine (tea colored), and bleeding or bruising more easily than normal

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Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; and changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness

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Kidney problems: decrease in your amount of urine, blood in your urine, swelling of your ankles, and loss of appetite

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Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in mouth or nose, throat, or genital area; fever or flu-like symptoms; and swollen lymph nodes

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Pancreas problems: pain in your upper stomach area (abdomen), severe nausea or vomiting, and loss of appetite

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Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with IMFINZI and IMJUDO. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include: Chest pain, irregular heartbeats, shortness of breath or swelling of ankles; confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems; tingling, numbness or weakness of the arms or legs; double vision, blurry vision, sensitivity to light, eye pain, changes in eye sight; persistent or severe muscle pain or weakness, muscle cramps, joint pain, joint stiffness or swelling; and low red blood cells and bruising

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Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include: chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, and back or neck pain

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Rejection of a transplanted organ or tissue. Your healthcare provider should tell you what signs and symptoms you should report and monitor you depending on the type of organ or tissue transplant that you have had

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Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with IMFINZI. Your healthcare provider will monitor you for these complications

Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with IMFINZI and IMJUDO. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with IMFINZI and IMJUDO if you have severe side effects

Before you receive IMFINZI and IMJUDO, tell your healthcare provider about all of your medical conditions, including if you:

  • have immune system problems such as Crohn's disease, ulcerative colitis, or lupus
  • have received an organ or tissue transplant, including corneal transplant
  • have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
  • have received radiation treatment to your chest area
  • have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
  • are pregnant or plan to become pregnant. IMFINZI and IMJUDO can harm your unborn baby

    Females who are able to become pregnant:

    • Your healthcare provider will give you a pregnancy test before you start treatment with IMFINZI and IMJUDO.
    • You should use an effective method of birth control during your treatment and for 3 months after the last dose of IMFINZI and IMJUDO.
      Talk to your healthcare provider about birth control methods that you can use during this time.
    • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with IMFINZI and IMJUDO.
  • are breastfeeding or plan to breastfeed. It is not known if IMFINZI and IMJUDO pass into your breast milk. Do not breastfeed during treatment and for 3 months after the last dose of IMFINZI and IMJUDO.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of IMFINZI and IMJUDO?

IMFINZI and IMJUDO can cause serious side effects (see above).

The most common side effects of IMFINZI when used in combination with IMJUDO and platinum-containing chemotherapy in adults with metastatic non-small cell lung cancer (mNSCLC) include nausea, feeling tired or weak, muscle or bone pain, decreased appetite, rash, and diarrhea.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of IMFINZI and IMJUDO. Ask your healthcare provider or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects related to AstraZeneca products . If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

Please see Full Prescribing Information including Medication Guide for IMFINZI and IMJUDO.

What are IMFINZI and IMJUDO?

IMFINZI and IMJUDO are prescription medicines used to treat adults with a type of lung cancer called NSCLC. IMFINZI may be used in combination with IMJUDO and chemotherapy that contains platinum when your NSCLC has spread to other parts of your body (metastatic) and your tumor does not have an abnormal “EGFR” or “ALK” gene.

It is not known if IMFINZI and IMJUDO are safe and effective in children.

Please see Full Prescribing Information including Medication Guide for IMFINZI and IMJUDO.

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This product information is intended for US consumers only.

IMFINZI and IMJUDO are registered trademarks and AstraZeneca Access 360 is a trademark of the AstraZeneca group of companies.

©2025 AstraZeneca. All rights reserved. US-94542; US-106881 Last Updated 12/25

©2025 AstraZeneca. All rights reserved. US-94542 Last Updated 12/24

Read full Important Safety Information

What are IMFINZI and IMJUDO?

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Important Safety Information

What is the most important information I should know about IMFINZI® (durvalumab) and IMJUDO® (tremelimumab-actl)?

IMFINZI and IMJUDO are medicines that may treat certain cancers by working with your immune system. IMFINZI and IMJUDO can...

IMFINZI and IMJUDO are medicines that may treat certain cancers by working with your...

Read full Important Safety Information

What are IMFINZI and IMJUDO?

IMFINZI and IMJUDO are prescription medicines used to treat adults with a type of lung cancer called NSCLC. IMFINZI may be used in combination with IMJUDO and chemotherapy that ...

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