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What questions should I ask my doctor?

IMFINZI + BCG may play a key role in treating high-risk NMIBC. The questions here can help guide your conversation with your doctor as you learn more about high-risk NMIBC and build your treatment plan together.

What is the goal of my treatment?

How long will I be on treatment?

What lifestyle changes, if any, will I need to make?

What is the stage of my cancer, and what does that mean?

What is the risk group of my cancer, and what does that mean?

How do immunotherapies like IMFINZI and BCG work?

How will I receive IMFINZI?

What are the possible side effects of IMFINZI?

How will I receive BCG?

What is “BCG induction”?

What is “BCG maintenance”? What is a maintenance treatment?

How can I prepare for the BCG treatment process?

Find answers to common questions about IMFINZI

Take me to FAQs

Important Safety Information

What is the most important information I should know about IMFINZI® (durvalumab)?

IMFINZI is a medicine that may treat certain cancers by working with your immune system. IMFINZI can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.

What is IMFINZI?

IMFINZI is a prescription medicine used in combination with Bacillus Calmette-Guérin (BCG) to treat a type of bladder cancer called high-risk non-muscle invasive bladder cancer (NMIBC) that has not spread into the muscle layer of the bladder, when you have not had prior treatment with BCG.

It is not known if IMFINZI is safe and effective in children.

Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:

  • NMIBC Lung Problem Symptoms Lung problems: cough, shortness of breath, and chest pain
  • NMIBC Intestinal Problem Symptoms Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; and severe stomach-area (abdomen) pain or tenderness
  • NMIBC Liver Problem Symptoms Liver problems: yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine (tea colored), and bleeding or bruising more easily than normal
  • NMIBC Hormonal Gland Symptoms Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; and changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness
  • NMIBC Kidney Problem Symptoms Kidney problems: decrease in your amount of urine, blood in your urine, swelling of your ankles, and loss of appetite
  • NMIBC Skin Problem Symptoms Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in mouth or nose, throat, or genital area; fever or flu-like symptoms; and swollen lymph nodes
  • NMIBC Pancreas Problem Symptoms Pancreas problems: pain in your upper stomach area (abdomen), severe nausea or vomiting, and loss of appetite
  • NMIBC Other Organ Problem and Symptoms Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with IMFINZI. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include: Chest pain, irregular heartbeats, shortness of breath or swelling of ankles; confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems; tingling, numbness or weakness of the arms or legs; double vision, blurry vision, sensitivity to light, eye pain, changes in eye sight; persistent or severe muscle pain or weakness, muscle cramps, joint pain, joint stiffness or swelling; and low red blood cells and bruising
  • NMIBC Infusion Reaction Signs and Symptoms Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include: chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, and back or neck pain
  • NMIBC Transplant Complications Symptoms Rejection of a transplanted organ or tissue. Your healthcare provider should tell you what signs and symptoms you should report and monitor you depending on the type of organ or tissue transplant that you have had
  • NMIBC Transplant Complications Symptoms Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious
    and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with IMFINZI. Your healthcare provider will monitor you for these complications

Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with IMFINZI. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with IMFINZI if you have severe side effects

Before you receive IMFINZI, tell your healthcare provider about all of your medical conditions, including if you:

  • have immune system problems such as Crohn's disease, ulcerative colitis,
    or lupus
  • have received an organ or tissue transplant, including corneal transplant
  • have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
  • have received radiation treatment
    to your chest area
  • have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
  • are pregnant or plan to become pregnant. IMFINZI can harm your unborn baby
    Females who are able to become pregnant:
    • Your healthcare provider will give you a pregnancy test before you start treatment with IMFINZI.
    • You should use an effective method of birth control during your treatment and for 3 months after the last dose of IMFINZI. Talk to your healthcare provider about birth control methods that you can use during this time.
    • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with IMFINZI.
  • are breastfeeding or plan to breastfeed. It is not known if IMFINZI passes into your breast milk. Do not breastfeed during treatment and for 3 months after the last dose of IMFINZI.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of IMFINZI?

IMFINZI can cause serious side effects (see above).

The most common side effects of IMFINZI when used with Bacillus Calmette-Guérin (BCG) in adults with high-risk NMIBC include increased liver function tests, urinary tract infection, increased level of potassium in blood, pain or discomfort with urination, decreased red blood cells (anemia), blood in urine, increased level of creatinine in the blood, muscle or bone pain, decreased lymphocyte counts, urinate more often, decreased level of sodium in the blood, feeling tired, rash, and fever.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of IMFINZI. Ask your healthcare provider or pharmacist for more information.

Call your doctor for medical advice
about side effects. You may report side
effects related to AstraZeneca
products Report side effects related to AstraZeneca products. If you prefer to report these to the FDA, either visit www.FDA.gov/
medwatch or call 1-800-FDA-10881-800-FDA-1088.

What is IMFINZI?

IMFINZI is a prescription medicine used in combination with Bacillus Calmette-Guérin (BCG) to treat a type of bladder cancer called high-risk non-muscle invasive bladder cancer (NMIBC) that has not spread into the muscle layer of the bladder, when you have not had prior treatment with BCG.

It is not known if IMFINZI is safe and effective in children.

Please see Full Prescribing Information including Medication Guide for IMFINZI.

Important Safety Information

What is the most important information I should know about IMFINZI® (durvalumab)?

IMFINZI is a medicine that may treat certain cancers by working with your immune system. IMFINZI can cause your immune system to attack normal organs and tissues in any area of your body and can

What is IMFINZI?

IMFINZI is a prescription medicine used in combination with Bacillus Calmette-Guérin (BCG) to treat a type of bladder cancer called high-risk non-muscle invasive bladder cancer (NMIBC) that has not spread into the muscle layer of the bladder, when you have not had prior treatment with BCG.

What is IMFINZI?

Read full Important Safety Information