Questions to ask your doctor

Questions about starting treatment:

Click + to see the questions.

Who will be part of my care team?

What is the goal of treatment before and after surgery (perioperative treatment)?

How will my care team work together to create a treatment plan for me?

What does the full treatment journey look like, before, during, and after surgery?

What is the difference between an immunotherapy and a chemotherapy medicine?

How could IMFINZI + chemotherapy* help me fight my stomach (gastric) or gastroesophageal junction cancer that can be removed with surgery?

How long will I be on treatment before surgery?

What are the possible side effects of IMFINZI?

How will I receive IMFINZI + chemotherapy?*

How many steps are there to complete treatment, and why is it important to complete all of them?

Can you tell me more about the procedure?

What should I know about eating habits or changes to my diet as I prepare for surgery?

How much of my stomach will be removed?

Will any other parts of my digestive system be affected?

How long will the recovery from surgery be?

What will follow-up care include?

How can I prepare for post-surgery treatment?

How will surgery affect how I eat and my lifestyle?

What should I expect during my recovery?

How soon after surgery will I start getting IMFINZI and chemotherapy* again?

What is the importance of coming back to receive treatment after surgery?

What are the possible side effects of IMFINZI?

How long would I receive treatment with IMFINZI and chemotherapy,* followed by IMFINZI alone, after surgery?

What types of support are available? How can I get in contact with support organizations?

Help prepare with an overview of treatment with IMFINZI + chemotherapy*

See the overview

*Fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT).

Important Safety Information

What is the most important information I should know about IMFINZI^® (durvalumab)?

IMFINZI is a medicine that may treat certain cancers by working with your immune system. IMFINZI can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.

Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:

What is IMFINZI?

IMFINZI is used in combination with FLOT prior to and after surgery followed by IMFINZI alone to treat adults with a type of stomach cancer called GC or GEJC that can be removed by surgery.

It is not known if IMFINZI is safe and effective in children.

Lung problems: cough, shortness of breath, and chest pain
Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; and severe stomach-area (abdomen) pain or tenderness
Liver problems: yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine (tea colored), and bleeding or bruising more easily than normal
Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; and changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness
Kidney problems: decrease in your amount of urine, blood in your urine, swelling of your ankles, and loss of appetite
Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in mouth or nose, throat, or genital area; fever or flu-like symptoms; and swollen lymph nodes
Pancreas problems: pain in your upper stomach area (abdomen), severe nausea or vomiting, and loss of appetite
Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with IMFINZI. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include: Chest pain, irregular heartbeats, shortness of breath or swelling of ankles; confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems; tingling, numbness or weakness of the arms or legs; double vision, blurry vision, sensitivity to light, eye pain, changes in eye sight; persistent or severe muscle pain or weakness, muscle cramps, joint pain, joint stiffness or swelling; and low red blood cells and bruising
Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include: chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, and back or neck pain
Rejection of a transplanted organ or tissue. Your healthcare provider should tell you what signs and symptoms you should report and monitor you depending on the type of organ or tissue transplant that you have had
Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with IMFINZI. Your healthcare provider will monitor you for these complications

Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with IMFINZI. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with IMFINZI if you have severe side effects

Before you receive IMFINZI, tell your healthcare provider about all of your medical conditions, including if you:

have immune system problems such as Crohn's disease, ulcerative colitis, or lupus
have received an organ or tissue transplant, including corneal transplant
have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
have received radiation treatment to your chest area
have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
are pregnant or plan to become pregnant. IMFINZI can harm your unborn baby
- Females who are able to become pregnant:
- Your healthcare provider will give you a pregnancy test before you start treatment with IMFINZI.
- You should use an effective method of birth control during your treatment and for 3 months after the last dose of IMFINZI.
  Talk to your healthcare provider about birth control methods that you can use during this time.
- Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with IMFINZI.
are breastfeeding or plan to breastfeed. It is not known if IMFINZI passes into your breast milk. Do not breastfeed during treatment and for 3 months after the last dose of IMFINZI.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of IMFINZI?

IMFINZI can cause serious side effects (see above).

The most common side effects of IMFINZI when used with fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) in adults with gastric cancer (GC) or gastroesophageal junction adenocarcinoma (GEJC) that can be removed by surgery include: diarrhea; nausea; inflammation of the nerves causing numbness, weakness, tingling, or burning pain of the arms and legs; feeling tired; hair loss; decreased appetite; rash; stomach (abdominal) pain; vomiting; muscle and joint pain; fever; and pain and sores in the mouth.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of IMFINZI. Ask your healthcare provider or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects related to AstraZeneca products. If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

Call your doctor for medical advice about side effects. You may report side effects related to AstraZeneca products. If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

Please see Full Prescribing Information including Medication Guide for IMFINZI.

What is IMFINZI?

IMFINZI is used in combination with FLOT prior to and after surgery followed by IMFINZI alone to treat adults with a type of stomach cancer called GC or GEJC that can be removed by surgery.

It is not known if IMFINZI is safe and effective in children.

Please see Full Prescribing Information including Medication Guide for IMFINZI.

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Important Safety Information

What is the most important information I should know about IMFINZI^® (durvalumab)?

What is the most important information I should know about IMFINZI?

IMFINZI is a medicine that may treat certain cancers by working with your immune system. IMFINZI can cause your immune system to attack normal organs and tissues in any area of your body and can affect the...

IMFINZI is a medicine that may treat certain cancers by working with your immune system. IMFINZI can cause your immune system...

Read full Important Safety Information

What is IMFINZI?

IMFINZI is used in combination with FLOT prior to and after surgery followed by IMFINZI alone to treat adults with a type of stomach cancer called GC or GEJC that can be removed by surgery.

This product information is intended for US consumers only.

IMFINZI is a registered trademark and
AstraZeneca Access 360 is a trademark of the
AstraZeneca group of companies.

©2025 AstraZeneca. All rights reserved.
US-96999 Last Updated 11/25