Unresectable Hepatocellular CarcinomaKelly: Moving through obstacles
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Play storyMickey and his wife, Carla, talk about Mickey's unresectable hepatocellular carcinoma (uHCC) diagnosis and what it was like to start treatment for this kind of liver cancer with IMFINZI® (durvalumab) + IMJUDO® (tremelimumab-actl).
Play storyMICKEY: Just because you wind up with a health problem doesn’t mean life’s over. It means that you find a person that can help you. My name is Mickey.
CARLA: My name is Carla and I'm Mickey's wife and his caregiver, and he was diagnosed with uHCC last year.
MICKEY: One night I went to bed, woke up several hours later, terrific stomach cramps, pains. And they recommended that I have a port put in so they could check my stomach.
CARLA: That whole week was nothing but oncologist, port placement, this scan, that scan. It was scary at first, just not knowing what treatment options we would have.
MICKEY: It leaves you with torn, mixed-up feelings because you don't know, am I gonna get better, am I gonna get worse? But to be very honest with you, once they diagnosed my problem, started me on treatments, it gave you a different mindset because you realize that there is hope that things will get better.
CARLA: When the doctor prescribed the IMFINZI and IMJUDO for Mickey, I had a lot of questions.
VOICEOVER: IMFINZI is a prescription medicine used in combination with IMJUDO to treat adults with a type of liver cancer that cannot be removed by surgery (unresectable hepatocellular carcinoma or uHCC).
CARLA: I went to IMFINZI.com and I got some really good education resources off of that website too.
MICKEY: I feel like the doctor I had was very upfront. He explained to me that I might have some after effects.
CARLA: I would just say that after his treatments, he did experience being tired.
MICKEY: Carla is very supportive. She goes with me to the doctor. And follows up as a caregiver, that I follow their instructions.
CARLA: My advice for someone who is a caregiver to a patient is to remember, you have to take care of yourself.
MICKEY: I look forward to every day now. Keep a positive attitude. If you need help, don't be afraid to ask for it.
VOICEOVER:
IMPORTANT SAFETY INFORMATION
What is the most important information I should know about IMFINZI® (durvalumab) and IMJUDO® (tremelimumab-actl)?
IMFINZI and IMJUDO are medicines that may treat certain cancers by working with your immune system. IMFINZI and IMJUDO can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.
Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:
Lung problems: cough, shortness of breath, and chest pain
Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; and severe stomach-area (abdomen) pain or tenderness
Liver problems: yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine (tea colored), and bleeding or bruising more easily than normal
Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; and changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness
Kidney problems: decrease in your amount of urine, blood in your urine, swelling of your ankles, and loss of appetite
Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in mouth or nose, throat, or genital area; fever or flu-like symptoms; and swollen lymph nodes
Pancreas problems: pain in your upper stomach area (abdomen), severe nausea or vomiting, and loss of appetite
Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with IMFINZI and IMJUDO. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include: Chest pain, irregular heartbeats, shortness of breath or swelling of ankles; confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems; tingling, numbness or weakness of the arms or legs; double vision, blurry vision, sensitivity to light, eye pain, changes in eye sight; persistent or severe muscle pain or weakness, muscle cramps, joint pain, joint stiffness or swelling; and low red blood cells and bruising
Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include: chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, and back or neck pain
Rejection of a transplanted organ or tissue. Your healthcare provider should tell you what signs and symptoms you should report and monitor you depending on the type of organ or tissue transplant that you have had
Complications, including graft-versus-host disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with IMFINZI. Your healthcare provider will monitor you for these complications
Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with IMFINZI and IMJUDO. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with IMFINZI and IMJUDO if you have severe side effects
Before you receive IMFINZI and IMJUDO, tell your healthcare provider about all of your medical conditions, including if you:
- have immune system problems such as Crohn's disease, ulcerative colitis, or lupus
- have received an organ or tissue transplant, including corneal transplant
- have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
- have received radiation treatment to your chest area
- have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
- are pregnant or plan to become pregnant. IMFINZI and IMJUDO can harm your unborn baby
Females who are able to become pregnant:- Your healthcare provider will give you a pregnancy test before you start treatment with IMFINZI and IMJUDO.
- You should use an effective method of birth control during your treatment and for 3 months after the last dose of IMFINZI and IMJUDO. Talk to your healthcare provider about birth control methods that you can use during this time.
- Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with IMFINZI and IMJUDO.
- are breastfeeding or plan to breastfeed. It is not known if IMFINZI and IMJUDO pass into your breast milk. Do not breastfeed during treatment and for 3 months after the last dose of IMFINZI and IMJUDO.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of IMFINZI and IMJUDO?
IMFINZI and IMJUDO can cause serious side effects (see above).
The most common side effects of IMFINZI and IMJUDO in adults with unresectable hepatocellular carcinoma (uHCC) include rash, diarrhea, feeling tired, itchiness, muscle or bone pain, and stomach (abdominal) pain.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of IMFINZI and IMJUDO. Ask your healthcare provider or pharmacist for more information.
Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of AstraZeneca prescription drugs by calling 1-800-236-9933.1-800-236-9933. If you prefer to report these to the FDA, call 1-800-FDA-1088.1-800-FDA-1088.
What are IMFINZI and IMJUDO?
IMFINZI is a prescription medicine used in combination with IMJUDO to treat adults with a type of liver cancer that cannot be removed by surgery (unresectable hepatocellular carcinoma or uHCC).
It is not known if IMFINZI and IMJUDO are safe and effective in children.
Please see full Prescribing Information, including Patient Information (Medication Guide) for IMFINZI at IMFINZI.com.
Mickey and his wife, Carla, talk about Mickey's unresectable hepatocellular carcinoma (uHCC) diagnosis and what it was like to start treatment for this kind of liver cancer with IMFINZI® (durvalumab) + IMJUDO® (tremelimumab-actl).
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Important Safety Information
What is the most important information I should know about IMFINZI® (durvalumab) and IMJUDO® (tremelimumab-actl)?
IMFINZI and IMJUDO are medicines that may treat certain cancers by working with your immune system. IMFINZI and IMJUDO can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.
What are IMFINZI and IMJUDO?
IMFINZI and IMJUDO are prescription medications that may treat certain cancers.
IMFINZI is used to treat adults with a type of lung cancer called NSCLC.
- IMFINZI may be used alone when your NSCLC has not spread outside your chest, cannot be removed by surgery, and has responded or stabilized with initial treatment with chemotherapy that contains platinum, given at the same time as radiation therapy.
- IMFINZI may be used in combination with chemotherapy that contains platinum prior to surgery and alone after surgery when your NSCLC is able to be removed by surgery, and your tumor does not have an abnormal “EGFR” or “ALK” gene.
- IMFINZI may be used in combination with IMJUDO and chemotherapy that contains platinum when your NSCLC has spread to other parts of your body (metastatic) and your tumor does not have an abnormal “EGFR” or “ALK” gene.
IMFINZI is used to treat adults with a type of lung cancer called SCLC.
- IMFINZI may be used alone when your LS-SCLC cannot be removed by surgery and has responded or stabilized after initial treatment with chemotherapy that contains platinum, given at the same time as radiation therapy.
- IMFINZI may be used with the chemotherapy medicines etoposide and either carboplatin or cisplatin as your first treatment when your SCLC has spread within your lungs or to other parts of the body (extensive-stage small cell lung cancer, or ES-SCLC).
IMFINZI is used in combination with chemotherapy medicines gemcitabine and cisplatin to treat adults with a type of cancer called BTC, including cancer of the bile ducts (cholangiocarcinoma) and gallbladder cancer, when your BTC has spread to nearby tissues (locally advanced), or has spread to other parts of the body (metastatic).
IMFINZI is used in combination with IMJUDO to treat adults with a type of liver cancer that cannot be removed by surgery (unresectable hepatocellular carcinoma or uHCC).
IMFINZI is used in combination with the chemotherapy medicines carboplatin and paclitaxel followed by IMFINZI alone to treat adults with a type of uterine cancer called endometrial cancer that has spread (advanced) or has come back (recurred), and a laboratory test shows that your tumor is mismatch repair deficient (dMMR).
IMFINZI is used in combination with Bacillus Calmette-Guérin (BCG) to treat a type of bladder cancer called high-risk non-muscle-invasive bladder cancer (NMIBC) that has not spread into the muscle layer of the bladder, when you have not had prior treatment with BCG.
IMFINZI may be used in combination with the chemotherapy medicines gemcitabine and cisplatin (neoadjuvant treatment) prior to surgical removal of your bladder followed by IMFINZI alone after surgery (adjuvant treatment) to treat a type of bladder cancer called muscle- invasive bladder cancer (MIBC) that has spread into the muscle layer of the bladder but not to other parts of the body.
IMFINZI is used in combination with FLOT prior to and after surgery followed by IMFINZI alone to treat adults with a type of stomach cancer called gastric cancer (GC) or gastroesophageal junction adenocarcinoma (GEJC) that can be removed by surgery.
It is not known if IMFINZI and IMJUDO are safe and effective in children.
Call or see your healthcare provider right away if you develop any new or worsening signs or symptoms, including:
Getting medical treatment right away may help keep these problems from becoming more serious. Your healthcare provider will check you for these problems during your treatment with IMFINZI and IMJUDO. Your healthcare provider may treat you with corticosteroid or hormone replacement medicines. Your healthcare provider may also need to delay or completely stop treatment with IMFINZI and IMJUDO if you have severe side effects
Before you receive IMFINZI and IMJUDO, tell your healthcare provider about all of your medical conditions, including if you:
- have immune system problems such as Crohn's disease, ulcerative colitis, or lupus
- have received an organ or tissue transplant, including corneal transplant
- have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic)
- have received radiation treatment to your chest area
- have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome
- are pregnant or plan to become pregnant. IMFINZI and IMJUDO can harm your unborn baby
Females who are able to become pregnant:
- Your healthcare provider will give you a pregnancy test before you start treatment with IMFINZI and IMJUDO.
- You should use an effective method of birth control during your treatment and for 3 months after the last dose of IMFINZI and IMJUDO. Talk to your healthcare provider about birth control methods that you can use during this time.
- Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with IMFINZI and IMJUDO.
- are breastfeeding or plan to breastfeed. It is not known if IMFINZI and IMJUDO pass into your breast milk. Do not breastfeed during treatment and for 3 months after the last dose of IMFINZI and IMJUDO.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
What are the possible side effects of IMFINZI and IMJUDO?
IMFINZI and IMJUDO can cause serious side effects (see above).
The most common side effects of IMFINZI when used alone in adults with NSCLC that cannot be removed by surgery include cough, feeling tired, inflammation in the lungs, upper respiratory tract infections, shortness of breath, and rash.
The most common side effects of IMFINZI when used with platinum-containing chemotherapy in adults with NSCLC that can be removed by surgery include low red blood cells (anemia), nausea, constipation, feeling tired, muscle or bone pain, and rash.
The most common side effects of IMFINZI when used in combination with IMJUDO and platinum-containing chemotherapy in adults with metastatic NSCLC include nausea, feeling tired or weak, muscle or bone pain, decreased appetite, rash, and diarrhea.
The most common side effects of IMFINZI when used alone in adults with limited-stage small cell lung cancer (LS-SCLC) include inflammation in the lungs and feeling tired or weak.
The most common side effects of IMFINZI when used with etoposide and either carboplatin or cisplatin in adults with extensive-stage small cell lung cancer (ES-SCLC) include nausea, feeling tired or weak, and hair loss.
The most common side effects of IMFINZI when used with gemcitabine and cisplatin in adults with biliary tract cancer (BTC) include feeling tired, nausea, constipation, decreased appetite, stomach (abdominal) pain, rash, and fever.
The most common side effects of IMFINZI and IMJUDO in adults with unresectable hepatocellular carcinoma (uHCC) include rash, diarrhea, feeling tired, itchiness, muscle or bone pain, and stomach (abdominal) pain.
The most common side effects of IMFINZI when used with carboplatin and paclitaxel in adults with endometrial cancer include inflammation of the nerves causing numbness, weakness, tingling or burning pain of the arms and legs; muscle or bone pain; nausea; hair loss; feeling tired; stomach (abdominal) pain; constipation; rash; decreased level of magnesium in the blood; increased liver function tests; diarrhea; vomiting; cough; decreased level of potassium in the blood; shortness of breath; headache; and increased level of alkaline phosphatase in the blood.
The most common side effects of IMFINZI when used with BCG in adults with high-risk non-muscle-invasive bladder cancer include increased liver function tests, urinary tract infection, increased level of potassium in blood, pain or discomfort with urination, decreased red blood cells (anemia), blood in urine, increased level of creatinine in the blood, muscle or bone pain, decreased lymphocyte counts, urinate more often, decreased level of sodium in the blood, feeling tired, rash, and fever.
The most common side effects of IMFINZI when used with gemcitabine and cisplatin in adults with muscle-invasive bladder cancer (MIBC) include decreased red blood cells (anemia), decreased white blood cells, increased level of creatinine in the blood, decreased level of sodium in the blood, nausea, increased liver function tests, decreased level of calcium in the blood, decreased blood platelet counts, feeling tired, increased level of potassium in the blood, decreased lymphocyte counts, constipation, decreased level of magnesium in the blood, decreased appetite, increased level of alkaline phosphatase in the blood, rash, fever, diarrhea, vomiting, and stomach (abdominal) pain.
The most common side effects of IMFINZI when used with fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) in adults with gastric cancer (GC) or gastroesophageal junction adenocarcinoma (GEJC) that can be removed by surgery include: diarrhea; nausea; inflammation of the nerves causing numbness, weakness, tingling, or burning pain of the arms and legs; feeling tired; hair loss; decreased appetite; rash; stomach (abdominal) pain; vomiting; muscle and joint pain; fever; and pain and sores in the mouth.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of IMFINZI and IMJUDO. Ask your healthcare provider or pharmacist for more information.
Call your doctor for medical advice about side effects. You may report side effects related to AstraZeneca products
. If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.
Call your doctor for medical advice about side effects. You may report side effects related to AstraZeneca products. If you prefer to report these to the FDA, either visit www.FDA.gov/medwatch or call 1-800-FDA-1088.
What are IMFINZI and IMJUDO?
IMFINZI and IMJUDO are prescription medications that may treat certain cancers.
IMFINZI is used to treat adults with a type of lung cancer called NSCLC.
- IMFINZI may be used alone when your NSCLC has not spread outside your chest, cannot be removed by surgery, and has responded or stabilized with initial treatment with chemotherapy that contains platinum, given at the same time as radiation therapy.
- IMFINZI may be used in combination with chemotherapy that contains platinum prior to surgery and alone after surgery when your NSCLC is able to be removed by surgery, and your tumor does not have an abnormal “EGFR” or “ALK” gene.
- IMFINZI may be used in combination with IMJUDO and chemotherapy that contains platinum when your NSCLC has spread to other parts of your body (metastatic) and your tumor does not have an abnormal “EGFR” or “ALK” gene.
IMFINZI is used to treat adults with a type of lung cancer called SCLC.
- IMFINZI may be used alone when your LS-SCLC cannot be removed by surgery and has responded or stabilized after initial treatment with chemotherapy that contains platinum, given at the same time as radiation therapy.
- IMFINZI may be used with the chemotherapy medicines etoposide and either carboplatin or cisplatin as your first treatment when your SCLC has spread within your lungs or to other parts of the body (extensive-stage small cell lung cancer, or
ES-SCLC).
IMFINZI is used in combination with chemotherapy medicines gemcitabine and cisplatin to treat adults with a type of cancer called BTC, including cancer of the bile ducts (cholangiocarcinoma) and gallbladder cancer, when your BTC has spread to nearby tissues (locally advanced), or has spread to other parts of the body (metastatic).
IMFINZI is used in combination with IMJUDO to treat adults with a type of liver cancer that cannot be removed by surgery (unresectable hepatocellular carcinoma or uHCC).
IMFINZI is used in combination with the chemotherapy medicines carboplatin and paclitaxel followed by IMFINZI alone to treat adults with a type of uterine cancer called endometrial cancer that has spread (advanced) or has come back (recurred), and a laboratory test shows that your tumor is mismatch repair deficient (dMMR).
IMFINZI is used in combination with Bacillus Calmette-Guérin (BCG) to treat a type of bladder cancer called high-risk non-muscle-invasive bladder cancer (NMIBC) that has not spread into the muscle layer of the bladder, when you have not had prior treatment with BCG.
IMFINZI may be used in combination with the chemotherapy medicines gemcitabine and cisplatin (neoadjuvant treatment) prior to surgical removal of your bladder followed by IMFINZI alone after surgery (adjuvant treatment) to treat a type of bladder cancer called muscle- invasive bladder cancer (MIBC) that has spread into the muscle layer of the bladder but not to other parts of the body.
IMFINZI is used in combination with FLOT prior to and after surgery followed by IMFINZI alone to treat adults with a type of stomach cancer called gastric cancer (GC) or gastroesophageal junction adenocarcinoma (GEJC) that can be removed by surgery.
It is not known if IMFINZI and IMJUDO are safe and effective in children.
Please see Full Prescribing Information including Medication Guide for IMFINZI and IMJUDO.
What are IMFINZI and IMJUDO?
Important Safety Information
What is the most important information I should know about IMFINZI® (durvalumab) and IMJUDO® (tremelimumab-actl)?
IMFINZI and IMJUDO are medicines that may treat certain cancers by working with your immune system. IMFINZI and IMJUDO can cause your immune system to attack normal organs and tissues in...
IMFINZI is a medicine that may treat...
Important Safety Information
What are IMFINZI and IMJUDO?
IMFINZI and IMJUDO are prescription medications that may treat certain cancers.
IMFINZI is used to treat adults with a type of lung cancer called NSCLC...
What is the most important information I should know about IMFINZI?
IMFINZI is a medicine that may treat certain cancers by working with your immune...
IMFINZI is a medicine that may treat certain cancers by working with your immune...
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Select your bladder cancer type
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